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Labels
- Age dependent Pharmacology
- Approach to the patient
- body action on drug
- Causes of diarrhea
- Common cold
- Comparison Between Type 1 and Type 2 Diabetes Mellitus
- CPR
- Diabetes Mellitus
- Diabetes Mellitus type 1
- diarrhea treatment
- drug absorption
- drug elimination
- drug excretion
- drug metabolism
- Epidemiology
- Epidimiology
- epiglottitis
- Fever.Fever Unknown Origin
- Hepatitis A
- Hepatitis a Transmission
- Hepatitis a Treatment
- High blood pressure
- Hypertension
- Infectious Diarrhea
- introduction to hypertension
- Laboratory studies
- Obesity
- Pathogenesis
- pharmacodynamic
- pharmacokinetics
- Prevalence ofThe public health cost of hypertension
- primary hypertension
- Some health complications associated with hypertension
- Sore Throat
- Symptoms
- Symptoms of diarrhea
- Total costs of hypertension
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Showing posts with label Age dependent Pharmacology. Show all posts
Age Dependent Pharmacology.
Age Dependent Pharmacology:
A. PEDIATRIC PHARMACOLOGY
1. Newborns have a greater percentage of weight from body water and less body
fat than adults.
a. A water-soluble drug will have a higher Vd (relative to body size) in children
than in adults.
b. A lipid-soluble drug will have a lower Vd (relative to body size) in children
than
2. Pl
in adults.
asma protein binding is reduced for approximately the first year.
3. Metabolism, especially oxidation and glucuronidation, is also reduced.
4. Glomerular filtration rate (GFR) and renal tubular function are reduced in
newborns.
B. GERIATRIC PHARMACOLOGY:
1. The elderly generally have
a. A smaller overall body mass and less lean body mass
b. A higher percentage of body fat and less body water
i. A water soluble drug will have a lower Vd than in a person of average age.
ii. A lipid soluble drug will have a higher Vd.
c. Reduced plasma albumin, which will reduce the amount of bound drug in the
plasma
d. Reduced renal excretion
e. Reduced hepatic metabolism of some drugs, especially Phase I reactions.
f. Other nonpharmacokinetic changes
i. Central nervous system (CNS) drugs often produce confusion.
ii. Cardiovascular drugs often have greater effects in the elderly patient because
the homeostatic mechanisms (e.g., baroreceptor reflexes) are sluggish.
2. Special care must be taken when prescribing drugs for the elderly.
a. Overall, elderly patients require smaller dosages of most drugs than young
adults.
b. Compliance issues (e.g., cost, complex dosage regimens, childproof packaging
that is difficult to open) are common in the elderly.
c. Drug safety is of particular concern due to the fact that elderly patients tend to have
reduced drug metabolizing capability, take multiple drugs, and have comorbidities.
This increases the risk of problems due to drug-drug interactions and side effects
Tag :
Age dependent Pharmacology,
